Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

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成果类型：

期刊论文

作者：

Yang, Kailin;Zeng, Liuting;He, Qi;Wang, Shanshan;Xu, Hao;...

通讯作者：

Ge, JW

作者机构：

[Xu, Hao; Yang, Kailin; Wang, Shanshan; Ge, Jinwen] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

[Yang, Kailin; Ge, Jinwen] Hunan Acad Chinese Med, Changsha, Hunan, Peoples R China.

[Zeng, Liuting] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing, Peoples R China.

[He, Qi] Peoples Hosp Ningxiang City, Dept Crit Care Med, Ningxiang, Peoples R China.

通讯机构：

[Ge, JW ] H

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

Hunan Acad Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

NLRP3 inflammasome;immune mechanism;inflammatory mechanism;ischemic stroke;natural plant products

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2024

卷：

页码：

1250918

DOI：

10.3389/fphar.2024.1250918

基金类别：

The research is supported by National Key Research and Development Project of China (No. 2018YFC1704904), the National Natural Science Foundation of China (81774174), the Provincial Discipline Construction Project of Hunan University of Chinese Medicine (Integrated Traditional Chinese and Western Medicine) and the Postgraduate Scientific Research Innovation Project of Hunan Province (CX20230800).

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization of blood vessels to facilitate timely reperfusion is the primary clinical approach; however, reperfusion itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates the NLRP3 inflammasome as a potential therapeutic target, playing a key role in cerebral ischemia and reperfusion injury. The aberrant expression and function of NLRP3 inflammasome-mediated inflammation in cerebral ischemia have garnered considerable atte...

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Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

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