期刊论文

中文

中国中药杂志

1001-5302

2005

30

7

526-530

10.3321/j.issn:1001-5302.2005.07.015

国家自然科学基金（39900199）； 湖南省自然科学基金（99JJY2003）； 中国博士后基金（2003034521）；

本校为其他机构

目的:观察参麦注射液对大鼠脑出血后迟发性神经细胞损伤的保护作用.方法:采用Rosenberg法复制大鼠脑出血模型,观察脑出血后大鼠海马CA1区神经细胞病理形态结构、神经细胞线粒体DNA缺失、C-myc基因、PDGF-A基因表达及参麦注射液的防治作用.结果:参麦注射液减少大鼠脑出血后海马CA1区锥体细胞凋亡数目,抑制血肿周围脑组织线粒体DNA片段缺失,参麦注射液对出血早期C-myc mRNA的表达无明显影响,但可使PDGF-A mRNA表达明显下调并时限延长.结论:参麦注射液可能通过调节PDGF表达对脑出血后迟发性神经细胞损伤修复有保护作用.

Objective: To observe protective effects of Shenmai (SM) injection on the delayed injury of the cerebral neurons in rat with intracerebral hemorrhage. Method: Rosenberg models of intracerebral hemorrhage was established and the effects of SM injection on the pathologic changes in neuronal structure, mitochondria-DNA (mtDNA) deletion, C-myc gene and expression PDGF-A gene in hippocampal CA1 areas, were investigated. Result: SM injection inhibited the apoptosis of pyramidal cells in the hippocampal CA1 areas, and decreased the degree of mtDNA deletion in the neurons in the injured area. SM injec...