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MR T2 mapping成像评估止痛健骨方治疗膝骨性关节炎关节软骨损伤疗效的实验研究

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成果类型:
期刊论文
论文标题(英文):
Evaluation of efficacy of Zhitong-Jiangu recipes in treatment of cartilage injury in osteoarthritis using MR T2 mapping: An experimental study
作者:
张堃;朱克俭;谭旭仪;黄刚;李平(李平);...
通讯作者:
Zhu, K.
作者机构:
[李平; 沈宏荣] Department of Radiology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China
Department of Internal Medicine, the Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, 410006, China
[黄刚; 谭旭仪] Department of Orthopedics, the Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, 410006, China
[朱璐] Department of Ultrasound, the People's Hospital of Hunan Province, Changsha, 410005, China
通讯机构:
[Zhu, K.] C
College of Integrated Traditional Chinese and Western Medicine, China
语种:
中文
关键词:
骨性关节炎;软骨;止痛健骨方;磁共振成像;T2图;基质金属蛋白酶1
关键词(英文):
Cartilage;Magnetic resonance imaging;Matrix metalloprotease 1;Osteoarthritis;T2 mapping;Zhitong-Jiangu recipes
期刊:
中国介入影像与治疗学
ISSN:
1672-8475
年:
2017
卷:
14
期:
11
页码:
694-698
基金类别:
国家自然科学基金青年科学基金项目(81603482、81503452) 湖南省自然科学基金资助项目(2016JJ6115) 湖南中医药大学校级青年教师科研基金项目(校行科字[2015]5号)
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
中西医结合学院
药学院
湖南省中医药研究院
摘要:
目的 探讨MR T2 mapping成像评价止痛健骨方治疗骨性关节炎软骨损伤疗效的价值.方法 采用木瓜蛋白酶关节腔注射法制作新西兰大白兔膝骨关节炎模型,根据治疗方法不同将48只新西兰大白兔随机分为正常对照组、模型对照组、盐酸氨基葡萄糖治疗组、止痛健骨方治疗组.各组治疗4周后行膝关节MR T2 mapping成像并对关节软骨基质金属蛋白酶1(MMP-1)含量进行免疫组化分析.比较各组间关节软骨T2值及关节软骨MMP-1含量的差异,并分析不同干预方法、关节软骨MMP-1含量与关节软骨T2值的相关性.结果 模型对照组关节软骨T2值高于其他3组(P均<0.01),其他3组间关节软骨T2值差异无统计学意义.盐酸氨基葡萄糖治疗模型...
摘要(英文):
Objective To explore the value of MR T2 mapping imaging in evaluation of the effection of Zhitong-Jiangu recipes in treatment of cartilage injury in osteoarthritis. Methods The models of osteoarthritis in the knee of New Zealand white rabbits were made with intra-articular injection of papain. Totally 48 New Zealand white rabbits were randomly divided into normal control group, model control group, glucosamine hydrochloride treatment group and Zhitong-Jiangu recipes treatment group. MR T2 mapping was performed on the knee and the content of MMP...

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