Changes in metabolites in raw and wine processed Corni Fructus combination metabolomics with network analysis focusing on potential hypoglycemic effects

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Siqian;Liu, Jian;Tan, Leihong;Wang, Yikun;Li, Jing;...

通讯作者：

Long, HP

作者机构：

[Zhou, Siqian; Long, HP; Liu, Jian; Long, Hongping] Hunan Univ Chinese Med, Ctr Med Res & Innovat, Hosp 1, Changsha, Peoples R China.

[Ding, Changsong; Zhou, Siqian; Wang, Yajing; Long, HP; Long, Hongping] Hunan Univ Chinese Med, Changsha, Peoples R China.

[Tan, Leihong] Hunan Univ Chinese Med, Dept Pharm, Hosp 2, Changsha, Peoples R China.

[Wang, Yikun] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China.

[Li, Jing] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China.

通讯机构：

[Long, HP ] H

Hunan Univ Chinese Med, Ctr Med Res & Innovat, Hosp 1, Changsha, Peoples R China.

Hunan Univ Chinese Med, Changsha, Peoples R China.

语种：

英文

关键词：

Corni Fructus;hypoglycemic;metabolomics;network analysis;wine-processed markers

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2023

卷：

页码：

1173747

DOI：

10.3389/fphar.2023.1173747

基金类别：

National Natural Science Foundation of China [81703694]; Hunan Administration of Traditional Chinese Medicine Project [2021216]; Hunan Provincial Department of Education Project [20C1415, 21B0371]; Discipline construction of Hunan University of Chinese Medicine [22JBZ025]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

第二中医临床医学院

药学院

摘要：

Introduction: Corni Fructus (CF) is a Chinese herbal medicine used for medicinal and dietary purposes. It is available commercially in two main forms: raw CF (unprocessed CF) and wine-processed CF. Clinical observations have indicated that wine-processed CF exhibits superior hypoglycemic activity compared to its raw counterpart. However, the mechanisms responsible for this improvement are not well understood. Methods: To address this gap in knowledge, we conducted metabolomics analysis using ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS) to c...

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Changes in metabolites in raw and wine processed Corni Fructus combination metabolomics with network analysis focusing on potential hypoglycemic effects

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