National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201096, 81401431]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ3443]; Hunan Province Science & Technology program [2013SK3041]
机构署名：
本校为其他机构
院系归属：
中医学院
摘要：
Toll-like receptor 4 (TLR4) is a transmembrane pattern-recognition receptor expressed in immune cells and the heart. Activation of TLR4 signaling during sepsis results in the release of cardiac depression mediators that may impair heart function. The present-study aimed to determine whether TLR4 contributes to development of severe sepsis-induced myocardial dysfunction. A cecum ligation and puncture (CLP) procedure was employed to establish severe sepsis models. Wild type (WT) and TLR4 knock-out (TLR4-KO) mice were divided into four groups: WT-...
