Knockout of Toll-like receptor 4 improves survival and cardiac function in a murine model of severe sepsis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Dan;Zhu, Yun;Ouyang, Min-Zhi;Zhang, Ming;Tang, Kui;...

通讯作者：

Zhang, M

作者机构：

[Zhou, Dan; Zhu, Yun; Ouyang, Min-Zhi; Zhang, Ming; Tang, Kui; Niu, Cheng-Cheng] Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.

[Li, Ling] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Med Basic Teaching Expt Ctr, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhang, M ] C

Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

caspase 3;death receptor;Fas ligand;immunoglobulin enhancer binding protein;interleukin 6;myeloid differentiation factor 88;myeloperoxidase;toll like receptor 4;toll like receptor adaptor molecule 1;troponin I;tumor necrosis factor;autacoid;biological marker;cytokine;immunoglobulin enhancer binding protein;myeloid differentiation factor 88;toll like receptor 4;animal experiment;animal model;animal tissue;Article;blood sampling;cell differentiation;cell infiltration;cell surface;comparative study;controlled study;disease severity;enzyme linked immunosorbent assay;heart function;heart rate;histopathology;immunocompetent cell;macrophage;male;mortality rate;mouse;neutrophil;neutrophil chemotaxis;nonhuman;reverse transcription polymerase chain reaction;sepsis;survival;survival rate;animal;apoptosis;cardiac muscle;deficiency;disease model;echocardiography;genetics;heart function test;heart ventricle function;immunology;knockout mouse;metabolism;mortality;pathology;sepsis;severity of illness index;Animals;Apoptosis;Biomarkers;Cytokines;Disease Models, Animal;Echocardiography;Heart Function Tests;Inflammation Mediators;Male;Mice;Mice, Knockout;Myeloid Differentiation Factor 88;Myocardium;Neutrophil Infiltration;Neutrophils;NF-kappa B;Sepsis;Severity of Illness Index;Survival Rate;Toll-Like Receptor 4;Ventricular Function

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

5368-5375

DOI：

10.3892/mmr.2018.8495

基金类别：

The present study was supported by the National Natural Science Foundation of China (grant nos. 81201096 and 81401431), Hunan Provincial Natural Science Foundation of China (grant no. 2017JJ3443) and the Hunan Province Science & Technology program (grant no. 2013SK3041). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Toll-like receptor 4 (TLR4) is a transmembrane pattern-recognition receptor expressed in immune cells and the heart. Activation of TLR4 signaling during sepsis results in the release of cardiac depression mediators that may impair heart function. The present-study aimed to determine whether TLR4 contributes to development of severe sepsis-induced myocardial dysfunction. A cecum ligation and puncture (CLP) procedure was employed to establish severe sepsis models. Wild type (WT) and TLR4 knock-out (TLR4-KO) mice were divided into four groups: WT-...

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Knockout of Toll-like receptor 4 improves survival and cardiac function in a murine model of severe sepsis

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