期刊论文

Effect of the Supplemented Naotaifang on the Vascular Dementia Rats＇ Learning and Memory and the Expression of the NR2A,NR2B in Hippocampus

中文

中南医学科学杂志

2095-1116

2014

42

1

17-20

10.15972/j.cnki.43-1509/r.2014.01.002

201213:湖南省中医药科研重点项目 13B083:湖南省教育厅青年项目 13C958:湖南省教育厅科学研究项目 2013TT2025:湖南省科技厅项目

本校为第一机构

目的 观察加味脑泰方对血管性痴呆(VaD)大鼠学习记忆的影响,同时检测海马区NR2A及NR2B表达情况以探讨其可能机制.方法 将36只SD大鼠随机均分成假手术组、模型组和加味脑泰方组.采用四血管阻断法制备血管性痴呆模型.Morris水迷宫评价大鼠学习记忆能力;应用免疫组织化学技术观察各组大鼠海马NR2A及NR2B的表达情况.结果加味脑泰方组逃避潜伏期(27.4±6.5 s)显著低于模型组(64.4±10.1 s),穿越平台次数(8.1±0.98次)显著多于模型组(5.6±0.8次),差异均有显著性(P

Objective To observe the effect of the supplemented Naotaifang on the Vascular dementia rats＇ learning and memory and the expression of the NR2A,NR2B in Hippocampus. Methods 36 rats were randomly divided into three groups,the dementia model was made using 4-vessel occlusion,the learning and memory was evaluated by Morris water maze;the expression of NR2A,NR2B was watched by the immunohistochemical technique. Results The escape latency in the SNTF group is （27.4±6.5）s,which is lower than that（64.4±10.1）s in the vehicle group（P〈0.05）;th...