Ethmopharmcology relevance: Ganfule(GFL),one of herbal medicines formula in china, has been widely used as the prevention of hepatic cirrhosis, hepatitical viral and liver cancer agent.However, its material basis that account for therapeutic effects and mechanisms of action at molecular-level remain unclear.Methods: Here, we constructed a computational systems approach that integrates druglikeness prescreening, ADME (absorption, distribution, metabolism, and excretion) prediction, molecular docking and multi-components, multi-targets, multi...