期刊论文

Peng Jun

英文

数字中医药(英文)

2096-479X

2019

2

3

136-146

10.1016/j.dcmed.2019.12.002

We thank for the funding support from the National Natural Science Foundation of China ( No. 81804150 and No. 81703920 ), Project funded by China Post-doctoral Science Foundation ( No. 2019M662790 ), Natural Science Foundation of Hunan Province, China ( No. 2019JJ50442 and No. 2019JJ40226 ), Research-based Learning and Innovative Experiment Program Project for Hunan University Students ( No. 2017280 ), Scientific Research Project of Hunan Traditional Chinese Medicine Administration ( No. 201780 ), Open Fund Project of Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine ( No. 2018YZD05 ), and Open Fund of the Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine ( No. 2018ZYX20 and No. 2018ZYX26 ).

本校为第一且通讯机构

Objective: To explore the molecular targets and associated potential pathways of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) in the treatment of retinitis pigmentosa (RP) by the approaches of network pharmacology and bioinformatics. Methods: The potential blood-entry active ingredients and targets of LF were retrieved by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). RP-related gene targets were retrieved through disease comprehensive databases. Protein-protein interaction (PPI) network of LF component-targe...