Network Pharmacology Approach to Investigate the Preventive Mechanism of Hunan Expert Group Recommended Chinese Medicine Prevention No. 2 Prescription Against COVID-19

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu Hua-Ying;Li Jing;Mao Yi-Zhi;Yuan Zhi-Ying;Li Feng;...

通讯作者：

Huang Hui-Yong

作者机构：

[Yi-Zhi M.; Hui-Yong H.; Zhi-Ying Y.; Hua-Ying W.; Jing L.] Provincial Key Laboratory of TCM Diagnostics, Hunan Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[Feng L.] Dental / Head and Neck Cancer Research Center, UCLA School of Dentistry, Los Angeles, CA 90095, United States

[Liang L.] Provincial Key Laboratory of TCM Diagnostics, Hunan Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, Dental / Head and Neck Cancer Research Center, UCLA School of Dentistry, Los Angeles, CA 90095, United States

通讯机构：

[Huang Hui-Yong] P

Provincial Key Laboratory of TCM Diagnostics, Hunan Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China

语种：

英文

关键词：

Coronavirus disease 2019 (COVID-19);Hunan expert group recommended Chinese medicine prevention No. 2 prescription (Pre-No. 2);Immune system;Network pharmacology

关键词(中文)：

湖南省专家组推荐新型冠状病毒肺炎中药预防用方二;新型冠状病毒肺炎;网络药理学;免疫系统

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2020

卷：

期：

页码：

116-132

DOI：

10.1016/j.dcmed.2020.06.005

基金类别：

We thank for the funding support from the Scientific Research Fund of Hunan Administration of TCM (No. KYGG06 and No. KYGG07).

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

Objective: To explore the possible preventive mechanism of Hunan expert group recommended Chinese medicine prescription of No. 2 (Pre-No. 2) against coronavirus disease 2019 (COVID-19) by network pharmacology method. Methods: The target proteins of effective components and active compounds in Pre-No. 2 were screened by searching the Tradi-tional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). A component-target-disease interac-tion network of Pre-No. 2 was constructed by Cytoscape 3.7.2, gene ontology (GO) analysis...

摘要(中文)：

目的采用网络药理学方法探讨湖南省专家组推荐的新型冠状病毒肺炎中药预防用方二(以下简称\"预防用方二\")可能的预防机制。方法通过检索TCMSP数据库筛选\"预防用方二\"中有效成分及其靶蛋白,利用Cytoscape 3.7.2构建\"预防用方二\"的\"有效成分-靶点-疾病相互作用网络\",DAVID进行GO分析和KEGG的富集分析。结果通过TCMSP数据库药代动力学活性化合物条件筛选到复方中的163个化合物,278个目标蛋白靶点,调控网络中靶点最多的成分为山奈酚、汉黄芩素、7-甲氧基-2-甲基异黄酮、刺芒柄花素、异鼠李素、甘草查尔酮A等成分。GO富集分析结果显示\"预防用方二\"可以调控对炎症反应、病毒过程、体液免疫反...

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Network Pharmacology Approach to Investigate the Preventive Mechanism of Hunan Expert Group Recommended Chinese Medicine Prevention No. 2 Prescription Against COVID-19

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