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Network pharmacology approach to screen hypoglycemic extracts from Coptidis rhizoma and study their targets and pathways

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成果类型:
期刊论文
作者:
Xiao, Liu;Li, Yi;Liu, Xin-guo;Yang, Quan-wei;Yang, Lei;...
通讯作者:
Wei, M.
作者机构:
[Xiao, Liu] Wuhan 1 Hosp, Wuhan 430022, Peoples R China.
[Huang, Lei; Huang, He-gui; Liu, Xin-guo; Li, Yi; Yang, Quan-wei] Wuhan 1 Hosp, Pharm Dept, Wuhan 430022, Peoples R China.
[Yang, Lei] First Hosp Hunan Univ Chinese Med, Pharm Dept, Changsha 410007, Peoples R China.
[Wei, Ming] Wuhan 3 Hosp, Phys Examinat Ctr, Wuhan 430060, Peoples R China.
通讯机构:
Physical Examination Center, Wuhan No. 3 Hospital, Wuhan, China
语种:
英文
关键词:
Coptidis rhizoma;Hypoglycemic effects;Network pharmacology;D (2) dopamine receptor (DRD2);Insulin-like growth factor 1 receptor
期刊:
Tropical Journal of Pharmaceutical Research
ISSN:
1596-5996
年:
2022
卷:
21
期:
7
页码:
1493-1498
基金类别:
scientific research project of traditional Chinese medicine of Hubei Provincial Health Commission [ZY2021M093]
机构署名:
本校为其他机构
摘要:
Purpose: To screen the hypoglycemic active ingredients of Coptidis rhizoma, and study their targets as well as signal pathways via network pharmacology. Methods: Fifty-nine ingredients of Coptidis rhizoma were screened. Their targets were confirmed by comparing with the hypoglycemic targets in DrugBank databases. The relationship between ingredients and targets was revealed through String database. The ingredient-target-passageway network was constructed. Coptidis rhizoma was soaked in boiling water and concentrated. Rat models were rendered di...

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