Tumor buster-where will the CAR-T cell therapy \'missile\' go? - 成果

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Tumor buster-where will the CAR-T cell therapy 'missile' go?

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qu, Chunrun;Zhang, Hao;Cao, Hui;Tang, Lanhua;Mo, Haoyang;...

通讯作者：

Zhixiong Liu<&wdkj&>Quan Cheng

作者机构：

[Mo, Haoyang; Long, Lifu; Qu, Chunrun; Zhang, Nan; Liu, Zhixiong; Zhang, Hao; Cheng, Quan; Wang, Zeyu; Liu, Fangkun; Zhang, Liyang; Yi, Zhenjie] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.

[Mo, Haoyang; Long, Lifu; Qu, Chunrun; Yi, Zhenjie; Yan, Luzhe] Cent South Univ, XiangYa Sch Med, Changsha, Hunan, Peoples R China.

[Mo, Haoyang; Long, Lifu; Qu, Chunrun; Liu, Zhixiong; Zhang, Hao; Cheng, Quan; Wang, Zeyu; Liu, Fangkun; Zhang, Liyang; Yi, Zhenjie] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.

[Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China.

[Cao, Hui] Hosp Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China.

通讯机构：

[Zhixiong Liu; Quan Cheng] D

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

语种：

英文

关键词：

CAR-T cell;Immunotherapy;Target;Cancer;Personalized treatment

期刊：

Molecular Cancer

ISSN：

1476-4598

年：

2022

卷：

期：

页码：

1-53

DOI：

10.1186/s12943-022-01669-8

基金类别：

This work was supported by the National Natural Science Foundation of China (NO.82073893, 82172685, 81873635, 81703622). Hunan Provincial Natural Science Foundation of China (NO. 2022JJ20095, 2018SK2101, 2018JJ3838), China Postdoctoral Science Foundation (NO. 2018 M633002), Hunan Provincial Health Committee Foundation of China (NO. 202204044869). Xiangya Hospital Central South University postdoctoral foundation.

机构署名：

本校为其他机构

院系归属：

临床医学院

摘要：

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-specific antigens, attack specific cancer cells, and bypass tumor cell apoptosis avoidance mechanisms to some extent. This method has been extensively used to treat hematologic diseases, but the therapeutic effect in solid tumors is not ideal. Tumor antigen escape, treatment-related toxicity, and...

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