CRISPRlnc: a machine learning method for lncRNA-specific single-guide RNA design of CRISPR/Cas9 system

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zitian Yang;Zexin Zhang;Jing Li;Wen Chen;Changning Liu*

通讯作者：

Changning Liu

作者机构：

[Zexin Zhang; Jing Li; Changning Liu] CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China

[Wen Chen] Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine , School of Medicine, Hunan University of Chinese Medicine, Changsha 410208 , China

College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China

[Zitian Yang] CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China<&wdkj&>College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China

通讯机构：

[Changning Liu] C

CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China

语种：

英文

关键词：

CRISPR/Cas9;machine learning;lncRNA;sgRNA

期刊：

BRIEFINGS IN BIOINFORMATICS

ISSN：

1467-5463

年：

2024

卷：

期：

DOI：

10.1093/bib/bbae066

基金类别：

This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA26030301); the National Natural Science Foundation of China (Grant No. 31970609); Top Talents Program in Science and Technology’ from Yunnan Province; and Startup Fund from Xishuangbanna Tropical Botanical Garden. The funders had no role in the study design, data collection, analysis and interpretation, or preparation of the manuscript. Publication costs are funded by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA26030301).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

CRISPR/Cas9 is a promising RNA-guided genome editing technology, which consists of a Cas9 nuclease and a single-guide RNA (sgRNA). So far, a number of sgRNA prediction softwares have been developed. However, they were usually designed for protein-coding genes without considering that long non-coding RNA (lncRNA) genes may have different characteristics. In this study, we first evaluated the performances of a series of known sgRNA-designing tools in the context of both coding and non-coding datasets. Meanwhile, we analyzed the underpinnings of t...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

CRISPRlnc: a machine learning method for lncRNA-specific single-guide RNA design of CRISPR/Cas9 system

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问