Background: Traditional Chinese medicine (TCM) has been shown to be effective in treating ischemic stroke (IS), and the combination of Angelicae Sinensis Radix (ASR) and Astragali Radix (AR) is a core TCM prescription that is widely acknowledged for its efficacy in IS treatment. This study utilized network pharmacology methods to explore the molecular mechanisms underlying the therapeutic effects of Angelicae Sinensis Radix and Astragali Radix in IS treatment, with preliminary validation conducted through molecular docking. Methods: Information on the structure, targets, main biological functi...