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Study on mechanism and molecular docking verification of Angelicae Sinensis Radix and Astragali Radix in treating ischemic stroke

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成果类型:
期刊论文
作者:
Da-Yuan Zhong;Hui Cheng;Hong-Sheng Luo;Yi-Hui Deng;Huan-Jie Li;...
通讯作者:
De-Liang Liu
作者机构:
[Da-Yuan Zhong; De-Liang Liu; Xue-Ming Ou; Ping-Wen Liu; Jia-Rong Li; Xiang-Bo Kong; Jia-Qi Chen] Department of Neurosurgery, Nanhai Hospital of Traditional Chinese and Western Medicine, Jinan University, Foshan 528200, China.
Institute of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
[Hong-Sheng Luo] Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Yi-Hui Deng] College of Integrative Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
[Huan-Jie Li] Preventive Treating Disease Center, Foshan Hospital of Traditional Chinese Medicine, Foshan 528099, China.
通讯机构:
[De-Liang Liu] D
Department of Neurosurgery, Nanhai Hospital of Traditional Chinese and Western Medicine, Jinan University, Foshan 528200, China.
语种:
英文
关键词:
Angelicae Sinensis Radix;Astragali Radix;ischemic stroke;network pharmacology;molecular docking
期刊:
TMR现代中药
ISSN:
2537-9798
年:
2023
卷:
6
期:
2
页码:
9-17
基金类别:
funded by the Natural Science Foundation of China(No.81874416) Science,Technology Innovation Team Project of Hunan(No.2020RC4050).
机构署名:
本校为其他机构
院系归属:
中西医结合学院
摘要:
Background: Traditional Chinese medicine (TCM) has been shown to be effective in treating ischemic stroke (IS), and the combination of Angelicae Sinensis Radix (ASR) and Astragali Radix (AR) is a core TCM prescription that is widely acknowledged for its efficacy in IS treatment. This study utilized network pharmacology methods to explore the molecular mechanisms underlying the therapeutic effects of Angelicae Sinensis Radix and Astragali Radix in IS treatment, with preliminary validation conducted through molecular docking. Methods: Information on the structure, targets, main biological functi...
摘要(中文):
Background:Traditional Chinese medicine(TCM)has been shown to be effective in treating ischemic stroke(IS),and...展开更多 Background:Traditional Chinese medicine(TCM)has been shown to be effective in treating ischemic stroke(IS),and the combination of Angelicae Sinensis Radix(ASR)and Astragali Radix(AR)is a core TCM prescription that is widely acknowledged for its efficacy in IS treatment.This study utilized network pharmacology methods to explore the molecular mechanisms underlying the therapeutic effects of Angelicae Sinensis Radix and Astrag...

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