会议论文

Relationship between Amygdala melanocortin receptor and TCM Stomach Fire Flaring Up

中文

2013

81-83

世界中联药膳食疗研究专业委员会换届大会暨第四届学术年会

世界中联药膳食疗研究专业委员会换届大会暨第四届学术年会论文集

2013-04-01

太原

世界中医药学会联合会<&wdkj&>山西省药膳养生学会

本校为第一机构

目的:探讨杏仁核黑皮质素受体(MCR)与"胃火亢盛"的相关性。方法:SD雄鼠随机分两组,行杏仁中央核(CeA)插管并分别注射MCR拮抗剂SHU9119 (1nmol,1ul1)和生理盐水(1ul),观察药物对动物摄食、摄水以及体重的影响。结果:与生理盐水对照组比较,CeA微量注射SHU9119,12小时内大鼠的摄食、摄水量分别为83.41±9.89 kcal、25.63±1.54 g,显著高于对照组52.14±3.34 kcal、15.97±3.41g(P＜0.01或P＜0.05);且这种效应在24小时内达到高峰,摄食、摄水量分别为157.30±16.05 kcal、50.50±3.60g(P＜0.01),且体质量增加为14.25±5.55 g(P＜0.01);而24小时后MC受体拮抗剂SHU9119促进摄食和摄水的效应逐步消失(P＞...

　　Objective: To explore the rehtionship between amygdala melanocortin receptor and TCM term Stomach Fire Flaring Up (SFFU).Methods: Male Sprague-Dawley (SD) rats were randomly divided into two groups, then receiving cannula implant in central nucleus of the amygdala (CeA), and were treated with MCR antagonist SHU9119 (1nmol, 1ul) and saline (1ul) respectively.The food intake and water intake, as well as body weight increase were measured.Results:compared to the saline treatment, injection of SHU9119 in CeA could increase the food and water in...