IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ai, Qidi;Chen, Chen;Chu, Shifeng;Luo, Yun;Zhang, Zhao;...

通讯作者：

Chen, Naihong

作者机构：

[Ai, Qidi; Chen, Naihong] Hunan Univ Chinese Med, Hunan Engn Technol Ctr Stand & Funct Chinese Herb, Changsha 410208, Hunan, Peoples R China.

[Ai, Qidi; Chen, Naihong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Ai, Qidi; Chen, Chen; Yang, Pengfei; Zhang, Xiaoling; Chen, Naihong; Gao, Yan; Zhang, Shuai; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Ai, Qidi; Chen, Chen; Yang, Pengfei; Zhang, Xiaoling; Chen, Naihong; Gao, Yan; Zhang, Shuai; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Ai, Qidi; Chen, Chen; Yang, Pengfei; Zhang, Xiaoling; Chen, Naihong; Gao, Yan; Zhang, Shuai; Zhang, Zhao; Chu, Shifeng] Peking Union Med Coll, Beijing 100050, Peoples R China.

通讯机构：

[Chen, Naihong] H

[Chen, Naihong] C

[Chen, Naihong] P

Hunan Univ Chinese Med, Hunan Engn Technol Ctr Stand & Funct Chinese Herb, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

CKLF1;IMM-H004;aged rats;cerebral ischemia;complication;inflammation

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2019

卷：

期：

DOI：

10.3390/ijms20071661

基金类别：

Hunan University of Chinese Medicine First-Class Disciple Construction Project [201803]; Project of NDRC; State Administration of Traditional Chinese Medicine [ZYBZH-Y-HUN-24]; Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [2016TP2008]; Open fund of Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [BG201701]; Hunan Provincial Key Laboratory for Standardization of Important Chinese Herbal Pieces [4981-0901020]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81730096, 81873026, 81730093]; National Mega-project for Innovative Drugs [2018ZX09711001-002-007, 2018ZX09711001-003-005, 2018ZX09711001-009-013]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; PUMC Graduate Education and Teaching Reform Project [10023201600801]; opening Program of Shanxi Key Laboratory of Chinese Medicine Encephalopathy [CME-OP-2017001]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

(1) Background: Chemokine-like factor 1 (CKLF1) is a chemokine with potential to be a target for stroke therapy. Compound IMM-H004 is a novel coumarin derivative screened from a CKLF1/C-C chemokine receptor type 4 (CCR4) system and has been reported to improve cerebral ischemia/reperfusion injury. This study aims to investigate the protective effects of IMM-H004 on cerebral ischemia injury and its infectious cardiopulmonary complications in adult and aged rats from the CKLF1 perspective. (2) Methods: The effects of IMM-H004 on the protection was determined by 2,3,5-triphenyltetrazolium chlorid...

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IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats

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