期刊论文

Study on effect of Huayu Jiedu Formula on levels of plasma TAT,F1＋2,D-dimer and vWF in MCAO rats

中文

中华中医药学刊

1673-7717

2016

34

4

843-846

10.13193/j.issn.1673-7717.2016.04.021

81373508:国家自然科学基金 12A105:教育厅项目 201319:湖南省中医药局科研项目 201606:湖南省中医药局科研项目 :湖南省重点学科中西医结合基础项目 :湖南省自然科学创新群体基金 :湖南省高等学校科技创新团队支持计划 13JJ6061:湖南省自然科学基金 14JJ2113:湖南省自然科学基金

本校为第一机构

目的:建立大脑中动脉闭塞（MCAO）大鼠模型,观察化瘀解毒法对MCAO大鼠血浆TAT、F1+2、v WF、D-二聚体含量的影响。方法:雄性SD大鼠56只,随机分为假手术组、模型组、阿加曲班对照组、活血化瘀组、清热解毒组、化瘀解毒法组及PDTC组。线栓法制备大鼠左侧大脑中动脉闭塞模型,分别于术前1 h和术后12 h各给予相应药物1次,术后24h取标本用于检测。结果:（1）造模后各组TAT、F1+2水平显著升高;各治疗组TAT、F1+2水平较模型组明显降低（均P

Objective： To observe the effect of Huayu Jiedu Formula on the levels of plasma TAT,F1 ＋ 2,D-dimer and v WF by establishing middle cerebral artery occlusion model in rats.Methods： All 56 male SD rats were randomly divided into sham-operation group,model group,Huoxue Huayu group,Qingre Jiedu group,Huayu Jiedu group,PDTC group,Argatroban group.Rat model of middle cerebral artery occlusion was established first and the corresponding drugs were given 1 h before operation and 12 h after operation and samples were taken out for medical analysis 24...