期刊论文

The Effect of Shenshuai Granule on the Expression of PAI-1 and MMP -2 in Renal Glomerular Mesangial Cells

中文

中华中医药学刊

1673-7717

2007

25

2

283-284

10.13193/j.archtcm.2007.02.92.wangxj.041

湖南省中医药管理局科研项目（202020）；

本校为第一机构

目的:探讨肾衰颗粒对肾小球系膜细胞纤溶酶原激活物抑制剂（PAI-1）及基质金属蛋白酶2（MMP-2）表达的影响。方法:培养大鼠系膜细胞随机分为5组每组8～10孔,空白组、模型组、对照组、肾衰颗粒高剂量组、肾衰颗粒低剂量组,经处理后用酶联免疫吸附双抗夹心法定量测定PAI-1和MMP-2的表达。结果:肾衰颗粒对大鼠肾小球系膜细胞PAI-1的表达有明显抑制作用（P

Objective： To investgate the effects of Shenshuai granule on the expression of PAl - 1 and MMP -2 in renal glomerular Mesangial cells. Methods ： Divide the proliferative Glomemlar mesangial cells induced by TNF - atrandomly into 5 groups,the PAI- 1 and MMP- 2 were quantitated by ELISA assay After being treated in different way. Results： Shenshuai keli inhibite the expression of PAI - 1 and stimulate MMP - 2. conclusion ： Shenshuaikeli may down regulate PAI - 1 and up reg...