期刊论文

Effects of Banxia Xiexin Decoction against Rats Stress -Induced Gastric Mucosal Injury and Content of Inflammatory Related Factor

中文

中华中医药学刊

1673-7717

2015

33

10

2400-2403,后插14

10.13193/j.issn.1673-7717.2015.10.029

湖南省中医药管理局项目（2012038） 湖南省教育厅项目（14C0868） 湖南中医药大学中医基础理论校级重点学科项目

本校为第一机构

目的:观察预先给予辛开苦降的代表方半夏泻心汤对水浸束缚应激大鼠血清IL-1β、IL-8、TNF-α、IL-10含量的影响,探讨辛开苦降法抗应激性胃黏膜损伤的作用机制。方法:SD大鼠随机分为空白组、模型组、中药组（半夏泻心汤）、西药组（奥美拉唑）。每组动物相应药物灌胃3 d。除空白组外,其他大鼠水浸束缚应激（WRS）造模。计算大鼠胃黏膜损伤指数（UI）,HE染色光镜下观察大鼠胃黏膜病理改变,酶联免疫法检测各组大鼠血清IL-1β、IL-8、TNF-α、IL-10的含量。结果:与空白组比较,模型组大鼠胃黏膜损伤指数明显升高,病理改变明显,促炎因子IL-1β、IL-8、TNF-α含量显著升高（P

Objective ：To observe the effect of Xinkai Kujiang representative formula Banxia Xiexin Decoction on restraint stress rats serum IL - 1β, IL - 8, TNF - α and IL - 10 contents and explore the mechanism of Xinkai Kujiang method against stress induced gastric mucosal injury. Methods：SD rats were randomly divided into four groups：blank group, model group, Chinese medicine group （ Banxia Xiexin Decoction）, western medicine group （Omeprazole）. Each animal was given corresponding drugs by garage for 3 days. Except the blank group, the other r...