期刊论文

Effect of Xianti Jiangzhi I on Leptin Signaling Pathway in Hypothalamus of Ovariectomized Rats

中文

中华中医药学刊

1673-7717

2016

34

9

2241-2244

10.13193/j.issn.1673-7717.2016.09.055

广东省科技计划项目（20138021800085） 清远市科技计划项目（2013A010）

本校为第一机构

目的：研究纤体降脂Ⅰ号对去卵巢大鼠下丘脑瘦素信号传导通路的影响,探讨其纤体降脂的作用机制。方法：72只200 g左右的SD大鼠按体质量随机抽出假手术组12只,造模组60只,造模组采用双侧去卵巢法造模,假手术组只切除卵巢周围相应质量的脂肪。造模成功后,造模组大鼠按体质量随机分为模型组、纤体降脂Ⅰ号高剂量组（13.2 g/kg）、中剂量组（6.6 g/kg）、低剂量组（3.3 g/kg）和戊酸雌二醇组,每组12只。术后第5天开始药物干预,模型组和假手术组给予相应体积的纯净水,持续13周。给药结束后,取下丘脑匀浆,酶联免疫法检测瘦素（Leptin,LP）、瘦素长形受体（OB-Rb）、神经肽Y（NPY）、α-促黑激素（α-M...

Objective：To study the effect of Xianti Jiangzhi I on the leptin signaling pathway in the hypothalamus of ovariectomized rats and investigate its mechanism in losing weight and reducing fat. Method： Seventy - two rats were ran- domly divided into sham group（ 12 ） and model group（60）. The model group＇s rats were ovariectomized and the sham groupg were excised the equal weight fat. After the modeling, the rats were randomly divided into model group, Xianti Jiangzhi I high - dose group,Xianti Jiangzhi I middle - dose group, Xianti Jiangzhi ...