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Interaction between linc01615 and miR-491-5p regulates the survival and metastasis of colorectal cancer cells

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成果类型:
期刊论文
作者:
Xiao, You;Hu, Fan;Li, Mei;Mo, Li;Xu, Chongsi;...
通讯作者:
Xie, Biao
作者机构:
[Hu, Fan; Li, Mei; Xie, Biao; Mo, Li; Xu, Chongsi; Wang, Xiaoyan; Xiao, You] Hunan Univ Chinese Med, Dept Anorectal Surg 1, Affiliated Hosp 2, 233 North Cai E Rd, Changsha 410005, Peoples R China.
[Nie, Jing] Hunan Slack King Lab Anim Co Ltd, Changsha 410125, Peoples R China.
[Yang, Lixia] Changsha Med Sch, Dept Canc, Affiliated Hosp 1, Changsha 410219, Peoples R China.
通讯机构:
[Xie, Biao] H
Hunan Univ Chinese Med, Dept Anorectal Surg 1, Affiliated Hosp 2, 233 North Cai E Rd, Changsha 410005, Peoples R China.
语种:
英文
关键词:
Colorectal cancer (CRC);linc01615;miR-491-5p;apoptosis;invasion
期刊:
Translational Cancer Research
ISSN:
2218-676X
年:
2020
卷:
9
期:
4
页码:
2638-2647
基金类别:
Department of Education Key Project of Hunan Province [15A024]; Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2016M602416]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81704089]; Postdoctoral Science Fund Special Grant of China [2017T100603]; Natural Science Foundation of Huan Provence [2018JJ3400]; Changsha City Outstanding Innovation Youth Program Changsha city [kq1707012]
机构署名:
本校为第一且通讯机构
院系归属:
第二中医临床医学院
摘要:
Background: The 5-year survival of colorectal cancer (CRC) has had no obvious improvement during the past decades, although a significant progress in treatments has been established. The molecular mechanisms that drive the progression of CRC are still unclear. This study aims to determine the biological activities of linc01615 and its regulatory microRNAs in CRC cells. Methods: The expression of linc016150 and miR-491-5p was measured in six CRC cell lines and one normal colon mucosal epithelial cell line. Their effects on cell proliferation, apoptosis, invasion, and migration were tested in Ca...

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