期刊论文

中文

时珍国医国药

1008-0805

2015

26

9

2049-2051

10.3969/j.issn.1008-0805.2015.09.001

国家自然科学基金（No.81274008） 湖南省科研条件创新专项（No.2011TT2050）

本校为第一机构

目的 从大鼠灌胃黄芩煎液的给药剂量、天数及采血时间方面开展试验,比较含药血浆与含药血清中黄芩苷,初步探讨建立规范的黄芩中药血浆药理方法.方法 大鼠灌胃黄芩煎液后,取其第1、3天给药后的1h,2h及第5天给药后1h、2h、6h、12h含药血浆和含药血清,采用HPLC-MS法,测定含药血浆和含药血清中黄芩苷含量.结果 大鼠灌胃黄芩3～5天取药后1h含药血浆与血清黄芩苷浓度相对较高.结论 为黄芩中药血浆药理方法学给药剂量、时间及采血时间提供了理论依据.

Objective In this study,from the dose and days administered orally to the times of blood samples collected were researched, Chinese medicine plasma pharmacology method of Huangqin Decoction（HQD） were initially discussion and established. Methods Rats were given by HQD in gavage（ig） , plasma and serum were collected at designed times：1,3 days after administration of 1 h ,2h and 5 days after administration of 1 h,2h, 6h, 12h. Drug - containing plasma and serum containing baicalin content were determinated via HPLC -MS method. Results In this...