Follistatin-like 1: A dual regulator that promotes cardiomyocyte proliferation and fibrosis

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Siyuan;Liu, Hua;Hu, Zhixi;Li, Lin;Yang, Yi

通讯作者：

Yang, Y

作者机构：

[Hu, Siyuan] Wuhan Sports Univ, Grad Sch, Wuhan, Peoples R China.

[Hu, Siyuan] Hunan Univ Chinese Med, Sch Sports Art, Changsha, Peoples R China.

[Liu, Hua; Yang, Yi] Wuhan Sports Univ, Coll Hlth Sci, Wuhan 430079, Peoples R China.

[Hu, Zhixi; Li, Lin] Hunan Univ Chinese Med, Inst Chinese Med Diag, Changsha, Peoples R China.

通讯机构：

[Yang, Y ] W

Wuhan Sports Univ, Coll Hlth Sci, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

endothelial nitric oxide synthase;follistatin like 1;glycoprotein;hydroxymethylglutaryl coenzyme A reductase kinase;mammalian target of rapamycin;mitogen activated protein kinase;mitogen activated protein kinase 1;mitogen activated protein kinase 3;nitric oxide;protein kinase B;protein p53;regulator protein;Smad protein;transforming growth factor beta1;unclassified drug;follistatin;follistatin related protein;FSTL1 protein, human;transforming growth factor beta;Akt/mTOR signaling;AMPK signaling;apoptosis;cardiac muscle cell;cardiovascular disease;cell proliferation;endurance training;evolution;exercise intensity;heart muscle fibrosis;heart protection;human;MAPK signaling;nonhuman;priority journal;protein function;regulatory mechanism;resistance training;Review;signal transduction;TGF beta signaling;cardiac muscle cell;cell proliferation;fibrosis;genetics;heart infarction;metabolism;pathology;Cell Proliferation;Fibrosis;Follistatin;Follistatin-Related Proteins;Humans;Myocardial Infarction;Myocytes, Cardiac;Signal Transduction;Transforming Growth Factor beta

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2020

卷：

235

期：

页码：

5893-5902

DOI：

10.1002/jcp.29588

基金类别：

This study was supported by the National Natural Science Foundation of China (81774208, 81700280, 81970261) to Zhixi Hu and Hua Liu; Natural Science Foundation of Hubei Province, China (2017CFB361) to Hua Liu; and Scientific Research Fund of Hunan Provincial Education Department, China (18C0360) to Siyuan Hu.

机构署名：

本校为其他机构

摘要：

Follistatin-like 1 (FSTL1) is a key factor in maintaining cardiac growth and development. It can be activated by exercise training and has a dual role in promoting cardiomyocyte proliferation and fibrosis, but its underlying mechanism is not fully understood. To elucidate the dual mechanism and target of FSTL1 regulating of cardiomyocyte proliferation and myocardial fibrosis, and the mechanism by which exercise-regulated FSTL1 improves cardiovascular disease, we explored the signal transduction pathway of FSTL1 promoting cardiomyocyte prolifera...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Follistatin-like 1: A dual regulator that promotes cardiomyocyte proliferation and fibrosis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问