作者机构：
[Tang, Zhenwang] S China Univ, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Peoples R China.;[Li, Xingsheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr Cardiol, Chongqing 400010, Peoples R China.;[Liao, Duanfang] Hunan Univ Chinese Med, Dept Pharmacol, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Tang, Zhenwang] S;S China Univ, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Peoples R China.
关键词：
The beta 2-adrenergic receptor gene;Polymorphism;Hypertension;Meta-analysis
摘要：
The beta 2-adrenergic receptor (beta 2-AR) gene has been implicated in the pathogenesis of hypertension. However, the results have been conflicting. In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in beta 2-AR gene with hypertension risk in Han Chinese population. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Eleven studies (2,058 cases and 1,459 controls) for 46A/G polymorphism and eight studies (2,219 cases and 1,495 controls) for 79C/G polymorphism were identified. The results suggested that 46A/G polymorphism G allele might increase the risk of hypertension (GG vs. AA: OR = 1.47, 95 % CI 1.20-1.82). However, no significant association was observed for 79C/G polymorphism (GG vs. CC: OR = 1.05, 95 % CI 0.61-1.79). The results indicated that 46A/G polymorphism in the beta 2-AR gene was associated with hypertension susceptibility in Han Chinese population.
摘要：
Objectives: To study the effects of group reminiscence therapy on depressive symptoms, self-esteem, and affect balance among community dwelling elderly. Methods: Eight communities were randomly selected from 372 eligible communities in Changsha city. They were randomly divided into four experimental groups and four control group. Geriatric Depression Scale (GDS) was used to screen entire 478 older adults living in these 8 communities. One hundred and sixty five of them had a GDS score between 11 and 25; among them, 125 participated in the study finally. The elderly group who were in the control group received health education, while the intervention group received both health education and group reminiscence therapy for 6 weeks. Both groups were assessed with the GDS, Self-Esteem Scale (SES), and Affect Balance Scale (ABS) before and after the 6-week-intervention. The results were analyzed using a mixed effect model with fixed effect of the intervention and random effect of the community, incorporating the structured randomness at the community level. Results: After 6 weeks' therapy, the GDS scores in the intervention group decreased significantly compared to those in the control group (p < 0.001). Scores on the positive affect subscale and affect balance in the intervention group increased significantly higher than control group, and scores on the negative affect subscale decreased significantly lower than control group (p < 0.01). After the intervention, there were no statistically significant differences in self-esteem scores between intervention and control groups. Conclusions: Group reminiscence therapy was effective in reducing symptoms of depression, improving affect balance, and promoting mental health of community-dwelling elderly. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
摘要：
Essential oils from the fruit of two species of Evodia rutaecarpa from China (Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang and Evodia rutaecarpa (Juss.) Benth.) have been obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry in order to discern the differences and similarities between the volatile chemical compositions of these species. More than 21 components were identified in essential oils of the studied plants. In the oil of E. rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang, the main essential oil ingredients were beta-myrcene (44.43%) and beta-pinene (39.88%). beta-pinene (72.82%), 1R-alpha-pinene (8.90%) and beta-myrcene (1.99%) were the major compounds in the oil of E. rutaecarpa (Juss.) Benth. The chemical compounds of the essential oils showed that there are only six common compounds between the two species.
摘要：
The purpose of this study was to provide a better understanding of the link between perfectionism and depression by examining the role of self-efficacy as a moderator in the relationship. Using a convenient sampling method, a sample of 570 university students completed Almost Perfect Scale-Revised (APS-R), General Self-Efficacy Scale (GSE) and The Beck Depression Inventory (BDI). Correlational analyses indicated that maladaptive perfectionism was positively correlated with depression, and negatively correlated with self-efficacy. In contrast, adaptive perfectionism was positively correlated with self-efficacy, and was not correlated with depression. Moreover, the present study confirms the moderating effect of self-efficacy between maladaptive perfectionism and depression in Chinese university students. The results support the notion that adaptive perfectionism is distinct from maladaptive perfectionism. Some practical implications of the present findings are discussed.
摘要：
One of our previous studies showed that Yizhijiannao Granule,a compound Chinese medicine, effectively improved the clinical symptoms of Alzheimer’s disease.In the present study,we established a model of Alzheimer’s disease using beta-amyloid(25-35)in PC12 cells,and treated the cells with Yizhijiannao Granule and its four monomers,i.e.,icariin,catechin,Panax notoginseng saponins,and eleutheroside E.Flow cytometry showed that Yizhijiannao Granule-containing serum, icariin,Panax notoginseng saponins,and icariin+Panax notoginseng saponins were protective against beta-amyloid(25-35)-induced injury in PC12 cells.Icariin in combination with Panax notoginseng saponins significantly inhibited early apoptosis of PC12 cells with beta-amyloid (25-35)-induced injury compared to icariin or Panax notoginseng saponins alone.The effects of icariin+Panax notoginseng saponins were similar to the effects of Yizhijiannao Granule.The findings indicate that two of the effective monomers of Yizhijiannao Granule,icariin and Panax notoginseng saponins,can synergistically inhibit early apoptosis of PC12 cells induced by beta-amyloid(25-35).
