期刊论文

中文

湖南中医药大学学报

1674-070X

2016

36

12

7-10

10.3969/j.issn.1674-070X.2016.12.002

国家自然科学基金项目（30801473,81603535）； 湖南省自然科学基金项目（14JJ3119）； 湖南中医药大学“中医经典理论与经方应用研究”科技创新团队项目;湖南中医药大学中医临床基础重点学科；

本校为第一机构

目的：观察凉膈散、银翘散对早期脓毒症炎症因子IL-1β、TNF-α、IL-10的不同干预作用。方法将40只新西兰大耳白兔随机分成空白对照组、模型组、银翘散治疗组、凉膈散治疗组、地塞米松对照组，采用耳缘静脉注射大肠杆菌内毒素的方法建立脓毒症模型，造模0.5 h 后药物干预，4 h 后观察兔一般情况及体温，检测血浆内毒素、促炎因子IL-1β、TNF-α及抗炎因子IL-10水平。结果银翘散组兔全身情况好转，体温、血浆内毒素、IL-1β、TNF-α的水平均比模型组降低（P＜0.01 or 0.05）；凉膈散组兔全身症状加重，体温、血浆内毒素、IL-1β、TNF-α、IL-10与模型组差异无统计学意义（P＞0.05）。结论银翘散能...

Objective To observe different effects of Liangge Powder and Yinqiao Powder on inflammatory cytokines IL-1β, TNF -α and IL -10 in early stage of sepsis. Methods 40 rabbits were randomly divided into blank con-trol group, model group, Yinqiao Powder therapy group, Liangge Powder therapy group and dexamethasone control group. The sepsis model was established by injecting LPS into rabbits' ear vein, which was given drug intervention after 0.5 h of modeling. After 4 h of modeling, the general conditions, temperatures, levels of plasma endotoxin, ...