期刊论文

中文

中华行为医学与脑科学杂志

1674-6554

2013

22

9

794-796

10.3760/cma.j.issn.1674-6554.2013.09.008

湖南省中医药管理局重点项目（60010288）；

本校为第一机构

目的 观测水通道蛋白(Aquaporins,AQPs)在慢性应激抑郁模型大鼠组织中的表达,探讨抑郁症部分躯体症状的发病机制.方法 采用慢性应激抑郁大鼠模型；将20只大鼠随机分为正常对照组和模型对照组,以免疫组化研究AQP4及AQP3、AQP8分别在抑郁模型大鼠海马及胃肠中的表达.结果 正常组及模型组大鼠海马中AQP4平均光密度分别为0.28 ±0.02、0.22 ±0.06,2组比较差异具有统计学意义(t值为2.756,P＜0.05)；2组胃及结肠黏膜中AQP3的表达差异无统计学意义(t值为1.814,1.812,P＞0.05).小肠黏膜中AQP3平均光密度值2组分别为0.15 ±0.02、0.17 ±0.02,差异有统计学意义(t值为2.769,P＜0.05).2组AQP8表达的平均光...

Objective To study the mechanisms of depression by exploring expressional differences of AQPs in the tissues of chronic stress depression rats. Methods Depression model was replicated by unpredicted chronic stress. 20 rats were randomly separated into normal control group and model control group, AQP4 and AQP3, AQP8 expressions on hippocampus and gastrointestinal mucosa of rat model with depression were detected by immunochemieal staining method. Results Means of optical density of AQP4 of normal group and model group hippocampus were 0.28 ± 0...