期刊论文

中文

中国针灸

0255-2930

2016

36

9

957-961

10.13703/j.0255-2930.2016.09.019

国家自然科学基金资助项目：81373717 湖南省高校创新平台开放基金项目：12K084 湖南中医药大学中医诊断学国家重点学科开放基金项目：2013ZYZD13 湖南省***卫生人才225工程培养项目

本校为第一机构

目的:观察电针对饮食诱导的单纯性肥胖(diet induced obesity, DIO)大鼠的体质量、胰岛素抵抗(insulin resistance, IR)及下丘脑胰岛素信号分子等的影响,探讨电针治疗肥胖症的机制。方法:50只SD雄性大鼠随机分为低脂组(10只)和高脂组(40只),分别以低脂饲料、高脂饲料喂养,高脂饲料组制造DIO大鼠模型。造模成功的30只大鼠,随机分为模型组、电针组、西药组,每组10只。电针组电针"后三里"和"曲池",每次20 min,每日1次,连续治疗28 d;西药组予以奥利司他灌胃,每日1次,共28 d;低脂组和模型组不做治疗。治疗结束后,HE染色观察肝脏组织形态学改变,采用生化和放射免疫法分别检测空腹血糖(fasting plasma ...

OBJECTIVE: To observe the effects of electroacupuncture (EA) on body weight, insulin resistance (IR) and hypothalamic insulin signal molecule in rats with diet-induced obesity (DIO), and to explore the action mechanism of EA on DIO. METHODS: Fifty SD male rats were randomly divided into a low fat diet (LFD) group (10 rats) and a high fat diet (HFD) group (40 rats). Rats were fed with LFD and HFD, respectively, and the DIO model was established in the HFD group. After the model was established, the rats were randomly divided intoa model group, an EA group and a medication group, ten rats in eac...