期刊论文

Peng, Q.-H.

中文

国际眼科杂志

1672-5123

2012

12

11

2053-2058

10.3969/j.issn.1672-5123.2012.11.03

国家中医药管理局重点学科建设项目； 湖南省教育厅科研基金资助项目（No.09C729）； 湖南省中医药科研基金资助项目（No.2010012）； 湖南省教育厅重点学科建设项目~~；

本校为第一且通讯机构

目的:通过建立实验性有色兔脉络膜新生血管(CNV)的动物模型,研究蛴螬提取物对血管生成素1(Ang1)和色素上皮衍生因子(PEDF)表达的影响,从而探讨其对CNV的抑制作用.方法:选取40只有色兔,随机分成5组,A组:健康空白组;B组:模型组;C组:维生素E组;D组:驻景丸加减方组;E组:蛴螬提取物组.每组8只16眼,通过氩激光光凝方式建立CNV模型.激光光凝后24h;7,14,21,28d行眼底彩色照相;7,14,21,28d行荧光素眼底血管造影(FFA);14,28d行光学相干断层扫描(OCT).然后将每组家兔随机分成2批,分别于14,28d用空气栓塞法处死并摘取眼球后段组织行切片、HE染色,光镜下观察视网膜组织病理形态学改变,并行Ang1和PEDF免疫组织...

To study the influence of holotrichia extractive to angiogenin1 (Ang1) and pigment epithelium derivation factor (PEDF) expression and probe its inhibiting effect to the choroidal neovascularization (CNV) though establishing CNV model of experimental colored rabbits. METHODS: Forty colored rabbits were selected and divided into 5 groups randomly, including blank group, model group, vitamin E group, zhujingwanjiajianfang group and the holotrichia extractive group. There were 8 rabbits in each group (16 eyes). CNV model was established through the method of argon laser photo-coagulation. Then opt...