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The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer

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成果类型:
期刊论文
作者:
Ren, Biqiong(任碧琼);Luo, Shudi;Xu, Fei;Zou, Guoying;Xu, Guofeng;...
通讯作者:
Ren, BQ
作者机构:
[Ren, Biqiong; He, Junyu; Zhu, Haowen; Ren, BQ; Li, Yong; Zou, Guoying; Xu, Guofeng; Xu, Fei] Hunan Prov Second Peoples Hosp, Clin Lab, 427 Furong Rd Changsha, Changsha 410007, Hunan, Peoples R China.
[Ren, Biqiong; He, Junyu; Zou, Guoying; Huang, Yiran; Xu, Guofeng; Luo, Shudi; Xu, Fei] Hunan Univ Tradit Chinese Med, Sch Clin Med, Changsha 410007, Hunan, Peoples R China.
通讯机构:
[Ren, BQ ] H
Hunan Prov Second Peoples Hosp, Clin Lab, 427 Furong Rd Changsha, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
Heat shock protein 70;Sperm-associated antigen 9;Auto-antibody;Hepatocellular carcinoma;Lung cancer
期刊:
CELL STRESS & CHAPERONES
ISSN:
1355-8145
年:
2017
卷:
22
期:
2
页码:
237-244
基金类别:
This work was supported by a research grant from the Health Department of Hunan Province Foundation (B2011-099) and Second People’s Hospital of Hunan Province Key Specialized Foundation.
机构署名:
本校为其他机构
院系归属:
临床医学院
摘要:
There are different views of how the immune system participates in the reaction to cancer. Here, we evaluated expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in patients with hepatocellular carcinoma (HCC) and lung cancer to explore tumor immunity. Our analysis showed that levels of HSP70 and SPAG9 antibody were significantly higher in the serum of lung cancer and HCC patients than in the serum of healthy subjects (P < 0.001), but there were no differences in levels of HSP70 antibody in patients and controls. Levels of serum SPAG9 antibody in newly diagnosed lung cancer patie...

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