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Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on Toll-like receptor pathway in female guinea pigs with recurrent genital herpes

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成果类型:
期刊论文
作者:
Kuang, Lin*匡琳);Deng, Yihui(邓奕辉);Liu, Xiaodan(刘晓丹);Zou, Zhixiang;Mi, Lan
通讯作者:
Kuang, Lin(匡琳
作者机构:
[Deng, Yihui; Liu, Xiaodan; Kuang, Lin] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
[Zou, Zhixiang] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.
[Mi, Lan] Hunan Univ Chinese Med, Hosp 2, Changsha, Hunan, Peoples R China.
[Kuang, Lin] Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Xueshi Rd 300, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Kuang, Lin] H
Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Xueshi Rd 300, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
acyclovir;herpes simplex virus 2;Longdanxiegan formula granule;recurrent genital herpes;Toll-like receptor pathway genes
期刊:
Taiwanese Journal of Obstetrics and Gynecology
ISSN:
1028-4559
年:
2016
卷:
55
期:
2
页码:
220-228
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202705, 81373641]; Scientific Research Fund of Department of Science and Technology of Hunan Province [2014FJ3024]
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
第二中医临床医学院
摘要:
Objective: The aim of the present study was to investigate the effects of Longdanxiegan formula granule (LDXGFG), a Chinese traditional medicine on Toll-like receptor (TLR) pathway in recurrent genital herpes. Materials and Methods: An experimental recurrent genital herpes model was constructed using herpes guinea pig model. The effect of LDXGFG on expression levels of TLR pathway genes were detected using real-time polymerase chain reaction. Furthermore, the dendritic cells and Langerhans cells were isolated and the TLR pathway genes of these cells were assayed after LDXGFG treatment. Results...

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