版权说明 操作指南
首页 > 成果 > 详情

MiR-340/iASPP axis affects UVB-mediated retinal pigment epithelium (RPE) cell damage

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Yan, Jiazhao;Qin, Yuhui;Yu, Jingsheng;Peng, Qinghua(彭清华);Chen, Xiangdong
通讯作者:
Qin, YH
作者机构:
[Yan, Jiazhao; Qin, Yuhui] Hunan Univ Chinese Med, Coll Tradit Chinese Med 1, Changsha 410208, Hunan, Peoples R China.
[Peng, Qinghua; Yu, Jingsheng; Chen, Xiangdong; Yan, Jiazhao] Hunan Univ Chinese Med, Hosp 1, Dept Ophthalmol, Changsha 410007, Hunan, Peoples R China.
[Qin, Yuhui] Hunan Univ Chinese Med, Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Qin, YH ] H
Hunan Univ Chinese Med, Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
caspase 3;inhibitory apoptosis stimulating proteins of the P53;microRNA;microRNA 340;peptides and proteins;protein p21;protein p53;unclassified drug;antagomir;caspase 3;cyclin dependent kinase inhibitor 1A;microRNA;MIRN340 microRNA, human;PPP1R13L protein, human;protein p53;repressor protein;signal peptide;small interfering RNA;TP53 protein, human;3' untranslated region;apoptosis;Article;cell proliferation;cell viability;controlled study;gene expression;human;human cell;priority journal;protein expression;protein RNA binding;retina injury;retina pigment cell;RNA interference;ultraviolet B radiation;antagonists and inhibitors;binding site;cell line;cell survival;cytology;genetics;metabolism;nucleotide sequence;radiation response;retinal pigment epithelium;sequence alignment;ultraviolet radiation;3' Untranslated Regions;Antagomirs;Apoptosis;Base Sequence;Binding Sites;Caspase 3;Cell Line;Cell Survival;Cyclin-Dependent Kinase Inhibitor p21;Gene Expression;Humans;Intracellular Signaling Peptides and Proteins;MicroRNAs;Repressor Proteins;Retinal Pigment Epithelium;RNA Interference;RNA, Small Interfering;Sequence Alignment;Tumor Suppressor Protein p53;Ultraviolet Rays
期刊:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN:
1011-1344
年:
2018
卷:
186
页码:
9-16
基金类别:
This study was supported by National Natural Science Foundation of China (No. 81303007 ).
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
Long-term exposure to ultraviolet B (UVB) light increases the risk of UVB damage due to increased UVB absorption by the retina and may further lead to age-related eye diseases. The retinal pigment epithelium (RPE) cell is a main target of UVB reaching the retina; its degeneration is an essential event in UVB-mediated age-related macular degeneration (AMD). Herein, we first evaluated the expression and effect of iASPP, an inhibitory regulator of apoptosis, in UVB-induced RPE cell damage. Through the mechanism of RNA interference at the post-tran...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com