期刊论文

Influence of lipid-lowering decoction on biochemical indexes in rats with nonalcoholic fatty liver disease

Deng, B.-X.

中文

世界华人消化杂志

1009-3079

2015

23

18

2942-2946

10.11569/wcjd.v23.i18.2942

湖南省科技厅基金资助项目,No.2014SK3040 湖南省大学生研究性学习和创新性实验计划基金资助项目,No.201210541018

本校为第一且通讯机构

目的:观察降脂理肝汤对非酒精性脂肪肝大鼠血脂、肝脂质、丙二醛（malondialdehyde,MDA）、超氧化物歧化酶（superoxide dismutase,SOD）、肿瘤坏死因子（tumor necrosis factor-α,TNF-α）等生化指标的影响.方法:通过高脂饮食诱导非酒精性大鼠脂肪肝模型,随机分为正常组、模型组、甘乐组（复方二氯醋酸二异丙胺5.5 mg/kg）、降脂理肝汤高、中、低剂量组（9.2、4.6、2.3 g生药/kg）,16 wk后取材,检测肝功能、血脂、肝脂质、MDA、SOD、TNF-α.结果:与模型组比较,降脂理肝汤组均可显著降低血清低密度脂蛋白（low-density lipoprotein,LDL）、游离脂肪酸（free fatty acids,FFA）、甘油三酯（trig...

AIM: To observe the effect of lipid-lowering decoction (LLD) on malondialdehyde (MDA), superoxide dismutase (SOD), and tumor necrosis factor-α (TNF-α) in rats with nonalcoholic fatty liver disease (NAFLD). METHODS: Fifty-eight male SD rats were fed a high-fat diet (HFD) for 16 wk to induce NAFLD, and 13 male SD rats were fed a normal diet (ND). After successful induction of NAFLD, NAFLD rats were randomly divided into a model group, a Ganle group, and low-, medium-, and highdose LLD groups. The LLD groups and Ganle group were given the corres...