期刊论文

Liu, ZH

英文

Peptides

0196-9781

2015

68

175-182

10.1016/j.peptides.2015.03.012

This work was supported by the National Basic Research Program of China (973 Program), grant No. 2010CB529801; the National Science Foundation Project, grant Nos. 31370783 and 31370817; the Science Found for Distinguished Young Scholars of Hunan Province (No. 14JJ1018); and the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (grant No. 20134486).

本校为其他机构

Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VGSC subtype mainly distributed in human cardiac myocytes. Among the four VGSC subtypes tested, hNav1.5 was the most sensitive to JZTX-II (EC50 = 125 ± 4 nM). Although JZTX-II had little or no effect on steady-state inactivation of ...