期刊论文

中文

中西医结合肝病杂志

1005-0264

2016

26

5

284-286+323

10.3969/j.issn.1005-0264.2016.05.011

湖南省教育厅重点项目（No.12A101）； 湖南中医药大学中医临床基础重点学科资助,湖南中医药大学校级青年基金（校行科字[2013]4号）,湖南中医药大学优秀青年教师培养计划项目；

本校为第一机构

目的：探讨清热解毒化浊片对内毒素血症（ETM）模型兔血浆内毒素、血常规、肝脏组织TLR4（Toll样受体4）／NF（核因子）-κB的影响。方法：将21只健康新西兰大耳白兔随机分为正常组、模型组，清热解毒化浊片组（简称清化组）。模型组及清化组兔分别从耳缘静脉注入大肠杆菌内毒素10μg／kg造模，正常组兔注入10μg／kg生理盐水。造模2h后灌胃。结果：灌胃后2h，各组兔分别于心脏采血检测血浆内毒素、血常规，免疫组化法观察各组兔肝脏组织TLR4、NF-κB的表达。与模型组比，清化组兔内毒素下降（P〈0．05）而WBC（白细胞计数）上升（P〈0．05），肝脏组织TLR4、NF-κB表达均下降（P〈0．05）。结论...

Objective： To explore the effect of Qingre Jiedu Huazhuo tablet on expression of endotoxin, blood Routine TLR4 and NF-κB signaling pathway in ETM rabbits Methods：The 21 healthy New Zealand big-eared rabbits were randomly divided into normal group, model group and Qingre JieDu Hua zhuo Plan group （ Qing Hua group）. Model group and Qing Hua group were injected with10μg/kg Escherichia Coli Endotoxin from the rabbit ear vein respectively to set model and the normal group were injected with 10 g/kg saline. Then the rabbits were gavaged and pla...