期刊论文

Deng, CQ

英文

AMERICAN JOURNAL OF CHINESE MEDICINE

0192-415X

2015

43

7

1419-1438

10.1142/S0192415X15500809

This study was supported by National Natural Science Foundation of China (Nos. 81102557 and 81573875), Doctoral Program Foundation of Higher Education of China (No. 20104323110001), Aid Project for Innovation Platform Open Fund of Hunan Province University (Nos. 11K050 and 14K068), Key Project of Administration of traditional Chinese Medicine of Hunan province (Nos. 201301 and 201509), General Project of Science and Technology Department of Hunan Province (No. 2014SK3001), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province for “Related research on prevention and treatment of cardio-cerebrovascular diseases with integrated traditional Chinese and Western Medicine”, Hunan Province Natural Science Innovation Group for “Fundamental research of Chinese medicine on prevention and treatment of cardio-cerebrovascular diseases”.

本校为第一且通讯机构

Astragalus and Panax notoginseng are commonly used to treat cardio-cerebrovascular diseases in China and are often combined together to promote curative effect. We speculate that the enhancement of the combination on anticerebral ischemia injury may come from the main active components. The purpose of this work was to probe the effects and mechanisms of Astragaloside IV (the active component of Astragalus) combined with Ginsenoside Rg1, Ginsenoside Rb1, and Notoginsenoside R1 (the active components of P. notoginseng) to antagonize ischemia/reperfusion (I/R) injury via inflammation and apoptos...