期刊论文

Tang, Y.-H.

中文

结合医学学报：英文版

2095-4964

2007

5

3

328-332

10.3736/jcim20070319

国家自然科学基金资助项目（No.30171132）；

本校为第一且通讯机构

目的:研究三七总皂苷(Panax notoginseng saponins, PNS)对大鼠脑缺血再灌注后白细胞介素-1β(interleukin-1β, IL-1β)、白细胞介素-1受体Ⅰ型(interleukin-1 receptor type Ⅰ, IL-1RⅠ)、白细胞介素-1受体拮抗剂(interleukin-1 receptor antagonist, IL-1ra)、细胞间黏附分子-1(intercellular adhesion molecule-1, ICAM-1)和半胱氨酸天冬氨酸特异性蛋白酶(cysteinyl-aspartate specific protease, caspase)-1、3、8 mRNA表达的影响.方法:采用颈内动脉线栓法建立大鼠局灶性脑缺血再灌注模型,在脑缺血前5 min和脑缺血后12 h分别腹腔注射给药1次.在脑缺血2 h再灌注22 h后,以逆转录-聚合酶链反...

OBJECTIVE: To investigate the effects of Panax notoginseng saponins (PNS) on mRNA expressions of interleukin-1 beta (IL-1 beta), interleukin-1 receptor type I (IL-1RI), interleukin-1 receptor antagonist (IL-1ra), intercellular adhesion molecule-1 (ICAM-1), cysteinyl-aspartate specific protease-1 (caspase-1), caspase-3 and caspase-8 after cerebral ischemia-reperfusion in rats. METHODS: Focal cerebral ischemia reperfusion in rats was induced by the method of nylon monofilament via the internal carotid artery. PNS was administered intraperitoneally respectively five minutes before cerebral ischem...