期刊论文

中文

中国中医药信息杂志

1005-5304

2014

21

11

62-65

10.3969/j.issn.1005-5304.2014.11.019

国家自然科学基金（81173188） 湖南省方剂学重点学科（2011--2015年） 致谢：本研究得到湖南师范大学生命科学院基因调控与研究实验室的鼎力支持!

本校为第一机构

目的：探讨甘露消毒丹体外抗肠道病毒71型(EV71)的作用。方法以病毒唑为对照药，运用细胞培养技术，通过直接抑毒实验、治疗性抑毒实验、预防性抑毒实验、预防＋治疗性抑毒实验4组实验观察甘露消毒丹体外抗EV71的病毒抑制率。结果在直接抑毒实验、治疗性抑毒实验、预防＋治疗性抑毒实验中，甘露消毒丹的EV71病毒抑制率高于病毒唑；在预防性抑毒实验中，甘露消毒丹与病毒唑的EV71病毒抑制率几乎为零。结论甘露消毒丹抗EV71作用强于病毒唑，且其抗EV71效应体现在影响EV71复制的多个环节。

Objective To explore anti-EV71 effects of Ganlu Xiaodudan in vitro. Methods Ribavirin was taken as control drug, with the help of cell culture to observe anti-EV71 inhibition rate of Ganlu Xiaodudan in inhibiting-virus-directly experiment, therapeutic-inhibiting-virus experiment, preventive-inhibiting-virus experiment and preventive-therapeutic-inhibiting-virus experiment. Results In inhibiting-virus-directly experiment, therapeutic-inhibiting-virus experiment and preventive-therapeutic-inhibiting-virus experiment, virus inhibition rate of Ganlu Xiaodudan was higher than ribavirin. In preventi...