期刊论文

Study on the Liver Function of Rats with Intestinal Endotoxemia Induced by Composite Factor

中文

中医药导报

1672-951X

2016

22

12

25-26+34

10.13862/j.cnki.cn43-1446/r.2016.12.008

12A101:湖南省教育厅重点项目 :湖南中医药大学中医临床基础重点学科建设项目 :湖南省方剂学重点学科建设项目

本校为第一机构

目的：探讨复合因素致肠源性内毒素血症（IETM）大鼠肝功能的变化。方法：将20只SD大鼠随机分为正常组和模型组,每组10只。用高脂、糖喂养模型组大鼠,同时予白酒（52°北京红星二锅头）灌胃,正常组予普通饲料且灌胃等剂量蒸馏水。12周后观察大鼠饲养情况,检测大鼠内毒素（LPS）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、谷氨酰转肽酶（GGT）指标及肝组织病变。结果：与正常组对比,模型组大鼠嗜睡、食欲不佳、毛发枯萎、大便溏;模型组血浆LPS升高（P〈0.05）,血清ALT、AST、ALP、GGT升高（P〈0.05）;模型组大鼠肝组织可见坏死、脂肪空泡及炎性浸润,正常组肝小叶...

Objective： To investigate the changes of the liver function of rats with intestinal endotoxemia （IETM） induced by composite factors. Methods： The 20 SD rats were randomly divided into normal group and model group, and 10 rats in each group. The model group was fed up with high amounts of sugars, fats and intragastic administration of 52% Beijing Red Star Erguoto liquor. Meanwhile the normal group was given ordinary food and administered with an equal volume of normal saline. After 12 weeks, plasma levels of lipopolysaccharide （LPS）, serum...