Aiming at the defect of low precision rate and low recall rate of traditional Chinese medicine (TCM) infor-mation retrieval based on keywords matching, we propose a semantic information retrieval model based on domain ontology of TCM by combining ontology with latent semantic indexing. Based on ontology concept-extended tree method of query expan-sion and semantic vector space, the model can map user queries and documents to the same latent semantic space, and re-turning retrieval results by calculating the similarity between the query vector...