期刊论文

中文

中医杂志

1001-1668

2014

55

16

1409-1411

10.13288/j.11-2166/r.2014.16.016

湖南省科技计划项目资助（2009JT3045） 湖南中医药大学青年教师科研基金课题

本校为第一机构

目的 探讨土鳖虫抗肿瘤的可能作用机制.方法 将56枚鸡胚制备成鸡胚绒毛尿囊膜(CAM)模型,随机分为空白组和土鳖虫含药血清高、中、低剂量组;每组14枚.空白组不处理,土鳖虫含药血清高、中、低剂量组分别加入经灌胃含土鳖虫生药11g/ (kg· d)、8g/ (kg·d)、5.5g/ (kg·d)剂量取得的大鼠土鳖虫含药血清,继续孵育72h后,观察各药物组鸡胚的存活情况、CAM模型的形态变化、CAM模型血管生成数量.结果 加药72h后,各组鸡胚存活率相当.存活鸡胚可见胚胎活动活跃,CAM透明,分布清晰且血管颜色鲜红.死亡鸡胚CAM血管颜色变浅,脉络不清,胚胎活动消失.土鳖虫含药血清高、中、低剂量组新生血管数量均少于空白组(P＜...

Objective To research the possible anti-neoplastic mechanism of Tubiechong （Eupolyphaga Seu Steleophaga）. Methods Totally 56 chick embryos were prepared into the chick chorioallantoic membrane （CAM） models and randomized into the blank group and Tubiechong-containing serum high-dose, middle-dose and low-dose groups. The blank group was given no treatment. The Tubiechong-containing serum high-dose, middle-dose and low- dose groups were given 11 g/kg·d, 8 g/kg·d and 5.5 g/kg·d Tubiechong-containing serum respectively. The in- cubation was ...