期刊论文

Influence of Xuefuzhuyu decoction on EPC repairing injured vascular endothelium

中文

中国药理学通报

1001-1978

2016

32

3

427-433

10.3969/j.issn.1001-1978.2016.03.025

国家自然科学基金青年项目（No81000494） 湖南省教育厅优秀青年基金（No10B076）

本校为第一机构

目的在中医活血化瘀理论指导下,将中医治疗和细胞疗法相结合,探讨血府逐瘀汤调控内皮祖细胞(EPC)修复大鼠损伤血管内皮的作用,并阐释其机制。方法以内皮损伤大鼠为受试对象,灌胃血府逐瘀汤并静脉输注EPC,探讨该方联合EPC输注后,对大鼠内皮损伤模型血管内皮损伤的修复作用,并从细胞分子环节阐释其机制。结果与单用EPC组和单用药物组比较,血府逐瘀汤联合EPC组内膜厚度明显减少(P

Aim: To investigate the role of Xuefuzhuyu decoction (XFZYD) combined with EPC in repairing damaged vascular endothelium using traditional Chinese medicine way of blood circulation combined with cell therapy. Methods: The repaired situation of injuried endothelium was observed and the effect of XFZYD on EPC was analysed after the endothelial injuried rats were gavaged XFZYD and vena caudalis injected EPC. Results: Compared with EPC group and XFZYD group, the XFZYD joint EPC group's endothelial thickness was reduced significantly (P < 0.05). And there appeared more significant role in lowering ...