期刊论文

Elephantiasis Shengjisan on chronic skin ulcers of TGF-β1 intervention

中文

中医药导报

1672-951X

2010

16

9

86-88,91

10.13862/j.cnki.cn43-1446/r.2010.09.041

湖南省中医药管理局科研资助项目（2008027）；

本校为第一机构

目的:观察象皮生肌散对慢性皮肤溃疡大鼠创面新生肉芽组织中转化生长因子β（1TGF-β1）水平的影响,探讨象皮生肌散对皮肤创面愈合的作用机理。方法:将90只SD大鼠随机分成象皮生肌散组,康复新液组和模型组,每组30只,依据文献复制了慢性皮肤溃疡模型,造模成功后各组每天换药1次,以上各组均以造模后换药直至处死为止。同时在光镜下观察换药后各组5 d、10 d创面周围组织生长情况。另组内再随机分成术后5 d、10 d 2个时间点,每个时间点处死10只大鼠,术前禁食,通过SABC免疫组化法检测大鼠创面新生肉芽组织中TGF-β1的表达量。结果:象皮生肌散组局部创面新生肉芽组织中TGF-β1的计数与分布面积都优于模...

Objective： To observe the elephant skin Shengjisan chronic skin ulcer on the wound granulation tissue in the rat transforming growth factor β1（TGF-β1） levels,of elephantiasis Shengjisan on the mechanism of skin wound healing.Methods： 90 SD rats were randomly divided into elephantiasis Shengjisan group,the new solution rehabilitation group and model group,n=30,based on the literature of chronic skin ulcer model copy,the modeling,dressing a day in each group times above are in each group were killed after modeling,dressing up to date.Meanwh...