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Efficient suppression of biofilm formation by a nucleic acid aptamer

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成果类型:
期刊论文
作者:
Ning, Yi(宁毅);Cheng, Lijuan(程莉娟);Ling, Min;Feng, Xinru;Chen, Lingli(陈伶利);...
通讯作者:
Deng, Le
作者机构:
[Cheng, Lijuan; Ning, Yi; Ling, Min; Wu, Minxi; Feng, Xinru; Deng, Le] Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Changsha 410081, Hunan, Peoples R China.
[Cheng, Lijuan; Ning, Yi; Chen, Lingli] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
[Deng, Le] Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Lushan Rd 36, Changsha 410081, Hunan, Peoples R China.
通讯机构:
[Deng, Le] H
Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Lushan Rd 36, Changsha 410081, Hunan, Peoples R China.
语种:
英文
关键词:
SELEX;Salmonella choleraesuis;aptamer;biofilm;biomarker;flagellin
期刊:
Pathogens and Disease
ISSN:
2049-632X
年:
2015
卷:
73
期:
6
页码:
ftv034
基金类别:
National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81271660, 81202451]; Specialized Research Fund of the Ministry of Education for the Doctoral Program of Higher Education [20114306110006]; Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; Hunan Provincial Education DepartmentHunan Provincial Education Department [09K021, 12K032]; Science and technology innovation team in Colleges and universities in Hunan Province 'Chinese traditional medicine for treatment of infectious diseases' [15]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Biofilms are microbial communities that are attached to a solid surface using extracellular polymeric substances. Motility and initial attachment mediated by flagella are required for biofilm formation. Therefore, blocking the motility of flagella is a potential strategy to inhibit biofilm formation. In this study, single-stranded DNA aptamers specific to the Salmonella choleraesuis were selected after 14 cycles of the systematic evolution of ligands by exponential enrichment (SELEX). Among the selected aptamers, the aptamer 3 showed the highes...

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