Efficient suppression of biofilm formation by a nucleic acid aptamer

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ning, Yi（宁毅）;Cheng, Lijuan（程莉娟）;Ling, Min;Feng, Xinru;Chen, Lingli（陈伶利）;...

通讯作者：

Deng, L

作者机构：

[Cheng, Lijuan; Ning, Yi; Ling, Min; Wu, Minxi; Feng, Xinru; Deng, Le] Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Changsha 410081, Hunan, Peoples R China.

[Cheng, Lijuan; Ning, Yi; Chen, Lingli] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

[Deng, Le] Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Lushan Rd 36, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Deng, L ] H

Hunan Normal Univ, Coll Life Sci, Dept Microbiol, Lushan Rd 36, Changsha 410081, Hunan, Peoples R China.

语种：

英文

关键词：

aptamer;flagellin;ligand;single stranded DNA;antiinfective agent;aptamer;protein binding;Article;atomic force microscopy;bacterial cell;binding affinity;biofilm;controlled study;dissociation constant;Escherichia coli;in vitro study;mass spectrometry;maximum binding capacity;nonhuman;priority journal;Salmonella enterica;Salmonella enterica serovar Paratyphi A;Staphylococcus aureus;systematic evolution of ligands by exponential enrichment aptamer technique;biofilm;drug effects;isolation and purification;metabolism;microscopy;physiology;Salmonella;Anti-Bacterial Agents;Aptamers, Nucleotide;Biofilms;Flagellin;Microscopy;Protein Binding;Salmonella;SELEX Aptamer Technique

期刊：

Pathogens and Disease

ISSN：

0928-8244

年：

2015

卷：

期：

页码：

ftv034

DOI：

10.1093/femspd/ftv034

基金类别：

We would like to thank National Natural Science Foundation (81271660, 81202451) and the Specialized Research Fund of the Ministry of Education for the Doctoral Program of Higher Education (20114306110006), the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province, A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (09K021, 12K032) and Science and technology innovation team in Colleges and universities in Hunan Province ‘Chinese traditional medicine for treatment of infectious diseases’ (No: 15) for the financial support.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Biofilms are microbial communities that are attached to a solid surface using extracellular polymeric substances. Motility and initial attachment mediated by flagella are required for biofilm formation. Therefore, blocking the motility of flagella is a potential strategy to inhibit biofilm formation. In this study, single-stranded DNA aptamers specific to the Salmonella choleraesuis were selected after 14 cycles of the systematic evolution of ligands by exponential enrichment. Among the selected aptamers, the aptamer 3 showed the highest affini...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Efficient suppression of biofilm formation by a nucleic acid aptamer

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问