The microRNA miR-17 regulates lung FoxA1 expression during lipopolysaccharide-induced acute lung injury

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成果类型：

期刊论文

作者：

Xu Zhaojun;Zhang Caiping;Cheng Lijuan（程莉娟）;Hu Mei（胡梅）;Tao Huai（陶怀）;...

通讯作者：

Song Lan（宋岚）

作者机构：

[Xu Zhaojun] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 41007, Hunan, Peoples R China.

[Cheng Lijuan; Tao Huai; Hu Mei; Song Lan] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Song Lan] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Song Lan; Zhang Caiping] Univ South China, Coll Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Song Lan] Hunan Univ Chinese Med, Coll Med, Dept Biochem & Mol Biol, 1 Xiangzui Rd,Hanpu Sci & Teaching Pk, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Song Lan] H

Hunan Univ Chinese Med, Coll Med, Dept Biochem & Mol Biol, 1 Xiangzui Rd,Hanpu Sci & Teaching Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Acute lung injury;Alveolar type II epithelial cells;FoxA1;Gene expression;miR-17

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2014

卷：

445

期：

页码：

48-53

DOI：

10.1016/j.bbrc.2014.01.108

基金类别：

Acknowledgments This work was support by funding from the Nature Science Foundation of China (81000026), the Natural Science Foundation of Hunan Province, China (No. 14JJ7060), the Science and Technology Project of Hunan Province, China (No. 2013SK3077), the Research Foundation of Education Bureau of Hunan Province, China (No. 13C691) and the Research Foundation of Stem Cell Regulation and Application, Hunan University of Chinese Medicine, China (Nos. 2013GXB01 and 2013GXB01).

机构署名：

本校为第一机构

院系归属：

医学院

中医学院

第一中医临床学院

药学院

摘要：

Acute lung injury (ALI) is a severe pulmonary disease that causes a high number of fatalities worldwide. Studies have shown that FoxA1 expression is upregulated during ALI and may play an important role in ALI by promoting the apoptosis of alveolar type II epithelial cells. However, the mechanism of FoxA1 overexpression in ALI is unclear. In this study, an in vivo murine model of ALI and alveolar type II epithelial cells injury was induced using lipopolysaccharide (LPS). LPS upregulated FoxA1 in the lung tissue of the in vivo ALI model and in L...

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The microRNA miR-17 regulates lung FoxA1 expression during lipopolysaccharide-induced acute lung injury

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