The gene of ligand of Numb-protein X1（LNX1） encodes two isoforms,which contain a NAPY domain and four PDZ domains.PDZ domain is found in many proteins for interacting with other proteins.The two isoforms are called LNX1-p70 and LNX1-p80（a kind of E3 ubiquitin ligase）.LNX1 could interact with a lot of proteins in cells,and affect the subcellular localization,quantity and function of these proteins.LNX1 could regulate embryonic development,and play an important role in role remodeling of tight junctions.It...
