Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats

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成果类型：

期刊论文

作者：

Xia Liu;Jun-Feng He*（何军锋）;Ya-Ting Qu（屈娅婷）;Zhi-Jun Liu;Qing-Yang Pu;...

通讯作者：

Jun-Feng He（何军锋）

作者机构：

[Liu X.; Liu Z.-J.; Guo S.-T.; Du J.; Jiang P.-F.] Institute of TCM Diagnostic, Hunan University of Chinese Medicine, Changsha, China

Liuyang Hospital of Traditional Chinese Medicine, Liuyang, China. Electronic address: 59421149@qq.com

[Qu Y.-T.; Pu Q.-Y.] Xiangxing College of Hunan University of Chinese Medicine, Changsha, China

[He J.-F.] Institute of TCM Diagnostic, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Liuyang Hospital of Traditional Chinese Medicine, Liuyang, China

通讯机构：

[Jun-Feng He] I

Institute of TCM Diagnostic, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Liuyang Hospital of Traditional Chinese Medicine, Liuyang, China

语种：

英文

关键词：

agouti related protein;insulin;protein tyrosine phosphatase 1B;tetrahydrolipstatin;agouti related protein;glucose blood level;insulin;neuropeptide Y;protein tyrosine phosphatase 1B;adipocyte;alternative medicine;animal cell;animal experiment;animal model;animal tissue;Article;body weight;controlled study;diet induced obesity;electroacupuncture;feces;hair;homeostasis;insulin resistance;insulin sensitivity;lipid diet;low fat diet;male;metabolic disorder;nonhuman;priority journal;protein expression;rat;weight reduction;adverse effects;animal;enzymology;female;genetics;glucose blood level;human;metabolism;obesity;Sprague Dawley rat;Agouti-Related Protein;Animals;Blood Glucose;Diet, High-Fat;Electroacupuncture;Female;Humans;Insulin;Insulin Resistance;Male;Neuropeptide Y;Obesity;Protein Tyrosine Phosphatase, Non-Receptor Type 1;Rats;Rats, Sprague-Dawley

期刊：

Journal of Acupuncture and Meridian Studies

ISSN：

2005-2901

年：

2016

卷：

期：

页码：

58-64

DOI：

10.1016/j.jams.2015.11.037

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81373717 ), the Fund of Open Innovation Platform in Hunan College (No. 12K084 ), the Fund of National Key Subjects of TCM Diagnostics of Hunan University of Chinese Medicine ( 2013ZYZD13 ) and the 225 Training Project of High-level Medical Talents of Hunan Province .

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

摘要：

Electroacupuncture (EA) has been shown to exert beneficial effects on obesity, but the mechanism is unclear. This study investigated the effects of EA on diet-induced obese (DIO) rats. Fifty male Sprague-Dawley rats were randomly divided into low-fat diet (LFD, 10 rats) and high-fat diet (HFD, 40 rats) groups. After the DIO models had been established, successful model rats were randomly divided into HFD, EA, and orlistat (OLST) groups. The EA group received EA at Zusanli (ST36) and Quchi (LI11) for 20 minutes once per day for 28 days. The OLST...

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Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats

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