期刊论文

Effects of YTT on Apoptosis and Expression of Actin In Aorta of Rat Models with IRS

中文

中华中医药学刊

1673-7717

2004

22

8

1434-1435

10.13193/j.archtcm.2004.08.72.lufg.036

湖南省教育厅科研项目

本校为第一机构

胰岛素抵抗综合征(insulin resistance syndrome,IRS)是以胰岛素抵抗为核心,同时并见高血糖、高血压、高血脂或冠心病等多种代谢性心血管疾病的综合征.研究表明,IRS的形成与血管平滑肌细胞(VSMC)凋亡紊乱有关,而肌动蛋白是诱导凋亡信号传递的重要因素.养心通脉片能有效提高机体的胰岛素敏感性,改善胰岛素抵抗,研究表明,健康对照组大鼠主动脉的APO和actinr测值均显著低于IRS病理模型组,提示IRS形成与细胞凋亡失常及肌动蛋白表达明显增高有关.目的:研究养心通脉片对胰岛素抵抗综合征(IRS)大鼠模型主动脉细胞凋亡及肌动蛋白信号传递的影响.方法:采取"高脂高糖高盐膳食"饲养法复制实验性IRS大鼠模型...

Objective:To investigate effects of Yangxin Tongmai Tabellae (YTT) on apoptosis and singnal transmission of actin in aort of rat modelswithinsulin resistance syndrome(IRS).Methods:Using the method of high fat-high glucose-high salt feeding to build the rat models with IRS,the rat models were randomly divided into 3 groups,YTT group,metformin (met) group and pathology group,as healthy controls group,which they were treated 30-days with YTT,met and pure water,respectively.The percentage of apoptosis and expression of actin in the aorta of rat mod...