期刊论文

Ouyang, Q.-C.

中文

中华肿瘤防治杂志

1673-5269

2013

20

19

1473-1477

10.3969/j.issn.1673-5269.2013.19.005

湖南省卫生厅科研计划（B2012-094）；

本校为其他机构

目的:比较不同剂量右丙亚胺对表柔比星诱导大鼠心肌损伤的干预作用及可能机制.方法:35只SD大鼠随机分5组,每组7只.对照组:于大鼠双侧腹腔分别注射生理盐水5 mL/kg,间隔时间为30 min,隔日1次,共4次(7 d)；模型组(表柔比星+生理盐水):大鼠腹腔内注射表柔比星4.5 mg/kg,隔日1次,共4次(7 d),注射表柔比星前30 min于另一区域腹腔内注射生理盐水5 mL/kg;表柔比星+低、中、高剂量右丙亚胺组:大鼠腹腔内注射表柔比星4.5 mg/kg,隔日1次,共4次(7 d),注射表柔比星前30 min于另一区域腹腔内注射右丙亚胺45、67.5和90 mg/kg,隔日1次,共4次(7 d).处死大鼠后检测各组大鼠心肌组织微量丙二醛(MDA)含量、总超氧化...

OBJECTIVE: To study the intervent function of different doses of dexrazoxane on myocardial injury induced by epirubicin in rats and its mechanism. METHODS: Thirty-five SD rats were randomly divided into five groups, each of seven. The rats in control group were given bilaterally intraperitoneal injection of saline 5 mL/kg, the interval time of 30 min, every other day, 4 times (7 d); In model group the rats were given intraperitoneal injection epirubicin 4.5 mg/kg every other day, 4 times (7 d), injection table dexrazoxane 30 min before epirubic...