期刊论文

Tang, B.

中文

世界华人消化杂志

1009-3079

2015

23

16

2532-2538

10.11569/wcjd.v23.i16.2532

湖南省科技厅基金资助项目,No.2014SK3040 湖南省大学生研究性学习和创新性实验计划基金资助项目,No.201210541018

本校为第一且通讯机构

目的:通过观察肝脏组织学的改变探讨降脂理肝汤对非酒精性脂肪肝（nonalcoholic fatty liver disease,NAFLD）大鼠肝组织病理学的影响.方法:71只♂SD大鼠,分为正常组（13只）和造模组（58只）,经高脂饮食诱导造模,经切片成功后,将剩余50只造模组大鼠随机分成模型组,甘乐组（复方二氯醋酸二异丙胺5.5 mg/kg）,降脂理肝汤高、中、低剂量组（9.2、4.6、2.3 g生药/kg）,16 wk后取材,取各组大鼠肝脏同一位置组织制作苏木精-伊红（HE）染色病理切片,观察各组鼠肝脏组织形态学的变化,根据肝组织学改变计算NAFLD活动度积分（NAFLD activity score,NAS）.结果:与正常组相比,模型大鼠肝脏脂肪变性明显,有些...

AIM: To observe the effect of lipid-lowering decoction (LLD) on morphological and pathological changes of liver tissue in rats with nonalcoholic fatty liver disease (NAFLD). METHODS: Fifty-eight male SD rats were fed a high-fat diet (HFD) for 16 wk to induce NAFLD, and 13 male SD rats were fed a normal diet (ND) as normal controls. After successful induction of NAFLD, 50 NAFLD rats were randomly divided into a model group, low-, medium-, and high-dose LLD groups, and a Ganle group. The LLD groups and Ganle group were given LLD (9.2, 4.6, 2.3 g/...