期刊论文

中文

现代生物医学进展

1673-6273

2017

17

21

4028-4031

10.13241/j.cnki.pmb.2017.21.007

国家自然科学基金项目（81102726） 湖南省高校科技创新团队感染性疾病中医药防治研究团队开放科研课题（Grxjb.18 Grxjb-14）

本校为第一机构

目的:通过观察补阳还五汤大鼠急性脊髓损伤后大脑神经元细胞凋亡及IL-17的表达的影响,探讨其神经保护机制。方法:SD大鼠24只,分成正常组、假手术组、SCI组、BYHWD组,通过在T3-T4横突间横断右侧半脊髓制备SCI模型,分别于手术前1d及术后1 d、1 w、4 w、8 w运动BBB评分评定大鼠后肢运动功能;术后8 w用Tunnel法检测神经细胞凋亡、免疫组化法检测大鼠神经细胞IL-17的表达。结果:BBB评分比较:SCI组、BYHWD组BBB评分明显低于正常组与假手术组,差异有统计学意义（P

Objective：To observe the effects of Buyang Huanwu Decoction on the apoptosis and expression of IL-17 in cortex neurons in rats after spinal cord injury,in order to explore the possible mechanisms of its neuro protection.Methods：24 SD rats were divided into normal group,sham operation group,SCI group and BYHWD group.SCI model was established in T3-T4 inter transverse the right half of spinal cord transaction.BBB score of rat hind limb motor function were assessed at 1 d before operation and 1 d,1 W,4 W,8 W after operation.After 8 W,Tunnel meth...