Intranasal Immunization of Mice to Avoid Interference of Maternal Antibody against H5N1 Infection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Fenghua;Peng, Bo;Chang, Haiyan;Zhang, Ran;Lu, Fangguo（卢芳国）;...

通讯作者：

Fang, Fang;Chen, Ze

作者机构：

[Fang, Fang; Zhang, Fenghua; Peng, Bo; Fang, F; Chen, Ze; Chang, Haiyan] Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China.

[Zhang, Ran] Hunan Normal Univ, Sch Med, Changsha, Hunan, Peoples R China.

[Lu, Fangguo] Hunan Univ Chinese Med, Sch Med, Changsha, Hunan, Peoples R China.

[Wang, Fuyan] Cent S Univ, Dept Immunol, Coll Basic Med Sci, Changsha, Hunan, Peoples R China.

[Chen, Ze] Shanghai Inst Biol Prod, Shanghai, Peoples R China.

通讯机构：

[Fang, F; Chen, Z] H

[Chen, Ze] S

Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China.

Shanghai Inst Biol Prod, Shanghai, Peoples R China.

语种：

英文

关键词：

Vaccines;Influenza;Enzyme-linked immunoassays;Immune response;H5N1;Viral vaccines;Vaccination and immunization;Influenza viruses

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2016

卷：

期：

页码：

e0157041-

DOI：

10.1371/journal.pone.0157041

基金类别：

Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province [20134486]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30972623]; Open Found of Hunan Provincial Key Laboratory for Molecular Microbiology [2014-04]; General Foundation of Hunan Provincial Science and Technology Department [2013SK3131]; Key Project of Hunan Province Program in the Field of Social Development [2015SK20331]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Maternally-derived antibodies (MDAs) can protect offspring against influenza virus infection but may also inhibit active immune responses. To overcome MDA- mediated inhibition, active immunization of offspring with an inactivated H5N1 whole-virion vaccine under the influence of MDAs was explored in mice. Female mice were vaccinated twice via the intraperitoneal (IP) or intranasal (IN) route with the vaccine prior to mating. One week after birth, the offspring were immunized twice via the IP or IN route with the same vaccine and then challenged with a lethal dose of a highly homologous virus st...

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